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rcgd 423  (Mebiol Inc)

 
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    Mebiol Inc rcgd 423
    Rcgd 423, supplied by Mebiol Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rcgd+423/rcgd+423/us11247974-1404-14-20
    Average 90 stars, based on 1 article reviews
    rcgd 423 - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Incubation:

    Article Title: Small molecules that enable cartilage rejuvenation
    Article Snippet: .. For 3-dimensional (3D) cell cultures adult human articular chondrocytes were incubated with or without RCGD 423 using 10% solution of Mebiol® hydrogel from Cosmo Bio (Carlsbad, Calif.) in X-vivo 15 serum free medium from Lonza (Walkersville, Md.) as described previously (Wu et al., 2014). ..

    Article Title: Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair
    Article Snippet: .. Together, these data demonstrate that RCGD 423 stimulates increases in adult chondrocyte proliferation and survival and suggest that pSTAT3 and MYC may mediate these effects. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3 caption a7 Regulator of cartilage growth and differentiation (RCGD) 423 inhibits apoptosis and promotes proliferation via induction of pSTAT3 and MYC in adult human chondrocytes. (A) Adult human articular chondrocytes were incubated with or without RCGD 423 and levels of MYC and pSTAT3 were quantified relative to histone H3 after 24 hours. (B) Increases in pSTAT3 and MYC proteins occurred in both a dose-dependent and time-dependent fashion following stimulation with RCGD 423. (C) Single human adult articular chondrocytes were cultured for 5 weeks with or without stimulation with RCGD 423 and assessed for colony formation. (D) Adult human articular chondrocytes were incubated with or without RCGD 423 in Mebiol hydrogel for 24 hours and then apoptotic cells were quantitated via flow cytometry for annexin V. (E) Proliferation in explants of adult pig articular cartilage in the absence or presence of RCGD 423 as shown by EdU incorporation. ..

    Cell Culture:

    Article Title: Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair
    Article Snippet: .. Together, these data demonstrate that RCGD 423 stimulates increases in adult chondrocyte proliferation and survival and suggest that pSTAT3 and MYC may mediate these effects. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3 caption a7 Regulator of cartilage growth and differentiation (RCGD) 423 inhibits apoptosis and promotes proliferation via induction of pSTAT3 and MYC in adult human chondrocytes. (A) Adult human articular chondrocytes were incubated with or without RCGD 423 and levels of MYC and pSTAT3 were quantified relative to histone H3 after 24 hours. (B) Increases in pSTAT3 and MYC proteins occurred in both a dose-dependent and time-dependent fashion following stimulation with RCGD 423. (C) Single human adult articular chondrocytes were cultured for 5 weeks with or without stimulation with RCGD 423 and assessed for colony formation. (D) Adult human articular chondrocytes were incubated with or without RCGD 423 in Mebiol hydrogel for 24 hours and then apoptotic cells were quantitated via flow cytometry for annexin V. (E) Proliferation in explants of adult pig articular cartilage in the absence or presence of RCGD 423 as shown by EdU incorporation. ..

    Flow Cytometry:

    Article Title: Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair
    Article Snippet: .. Together, these data demonstrate that RCGD 423 stimulates increases in adult chondrocyte proliferation and survival and suggest that pSTAT3 and MYC may mediate these effects. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3 caption a7 Regulator of cartilage growth and differentiation (RCGD) 423 inhibits apoptosis and promotes proliferation via induction of pSTAT3 and MYC in adult human chondrocytes. (A) Adult human articular chondrocytes were incubated with or without RCGD 423 and levels of MYC and pSTAT3 were quantified relative to histone H3 after 24 hours. (B) Increases in pSTAT3 and MYC proteins occurred in both a dose-dependent and time-dependent fashion following stimulation with RCGD 423. (C) Single human adult articular chondrocytes were cultured for 5 weeks with or without stimulation with RCGD 423 and assessed for colony formation. (D) Adult human articular chondrocytes were incubated with or without RCGD 423 in Mebiol hydrogel for 24 hours and then apoptotic cells were quantitated via flow cytometry for annexin V. (E) Proliferation in explants of adult pig articular cartilage in the absence or presence of RCGD 423 as shown by EdU incorporation. ..



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    Conversion of RAW264.7 pre-osteoclasts into iTS cells by the treatment with BML284. CN = control, CM = conditioned medium, RAW = RAW264.7 osteoclasts, MC3T3 = MC3T3 osteoblasts, MSC = mesenchymal stem cells, A5 = MLO-A5 osteocytes, 231 = MDA-MB-231 breast cancer cells, EO = EO771 mammary tumor cells, and 4T1.2 = 4T1.2 mammary tumor cells. ** p < 0.01 vs. CN, while ## p < 0.01 vs. A5 CM. ( A – D ) MTT-based viability of EO771 mammary tumor cells in response to a chemically treated conditioned medium, derived from MLO-A5 osteocytes, MSCs, MC3T3 osteoblasts, and RAW264.7 osteoclasts, respectively. NS = NSC228155 (EGF activator), RC = <t>RCGD423</t> (JAK/STAT activator), m3 = m-3M3FBS (phospholipase C activator), CW = CW008 (PKA activator), OA = OAC2 (Oct4 activator), YS = YS49 (PI3K activator), and BM = BML284 (Wnt activator). ( E , F ) Tumor selectivity of the inhibitory action of RAW CM, examined tumor selectivity of the inhibitory action using 3 tumor cell lines (MDA-MB-231 breast cancer cell line using 3 tumor cell lines (MDA-MB-231 breast cancer cell line, EO771 mammary tumor cell line, and 4T1.2 mammary tumor cell line), and KTB6 human breast epithelial cells. ( G ) Reduction in PTHrP in BM CM.
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    Image Search Results


    Conversion of RAW264.7 pre-osteoclasts into iTS cells by the treatment with BML284. CN = control, CM = conditioned medium, RAW = RAW264.7 osteoclasts, MC3T3 = MC3T3 osteoblasts, MSC = mesenchymal stem cells, A5 = MLO-A5 osteocytes, 231 = MDA-MB-231 breast cancer cells, EO = EO771 mammary tumor cells, and 4T1.2 = 4T1.2 mammary tumor cells. ** p < 0.01 vs. CN, while ## p < 0.01 vs. A5 CM. ( A – D ) MTT-based viability of EO771 mammary tumor cells in response to a chemically treated conditioned medium, derived from MLO-A5 osteocytes, MSCs, MC3T3 osteoblasts, and RAW264.7 osteoclasts, respectively. NS = NSC228155 (EGF activator), RC = RCGD423 (JAK/STAT activator), m3 = m-3M3FBS (phospholipase C activator), CW = CW008 (PKA activator), OA = OAC2 (Oct4 activator), YS = YS49 (PI3K activator), and BM = BML284 (Wnt activator). ( E , F ) Tumor selectivity of the inhibitory action of RAW CM, examined tumor selectivity of the inhibitory action using 3 tumor cell lines (MDA-MB-231 breast cancer cell line using 3 tumor cell lines (MDA-MB-231 breast cancer cell line, EO771 mammary tumor cell line, and 4T1.2 mammary tumor cell line), and KTB6 human breast epithelial cells. ( G ) Reduction in PTHrP in BM CM.

    Journal: Cancers

    Article Title: Conversion of Osteoclasts into Bone-Protective, Tumor-Suppressing Cells

    doi: 10.3390/cancers13225593

    Figure Lengend Snippet: Conversion of RAW264.7 pre-osteoclasts into iTS cells by the treatment with BML284. CN = control, CM = conditioned medium, RAW = RAW264.7 osteoclasts, MC3T3 = MC3T3 osteoblasts, MSC = mesenchymal stem cells, A5 = MLO-A5 osteocytes, 231 = MDA-MB-231 breast cancer cells, EO = EO771 mammary tumor cells, and 4T1.2 = 4T1.2 mammary tumor cells. ** p < 0.01 vs. CN, while ## p < 0.01 vs. A5 CM. ( A – D ) MTT-based viability of EO771 mammary tumor cells in response to a chemically treated conditioned medium, derived from MLO-A5 osteocytes, MSCs, MC3T3 osteoblasts, and RAW264.7 osteoclasts, respectively. NS = NSC228155 (EGF activator), RC = RCGD423 (JAK/STAT activator), m3 = m-3M3FBS (phospholipase C activator), CW = CW008 (PKA activator), OA = OAC2 (Oct4 activator), YS = YS49 (PI3K activator), and BM = BML284 (Wnt activator). ( E , F ) Tumor selectivity of the inhibitory action of RAW CM, examined tumor selectivity of the inhibitory action using 3 tumor cell lines (MDA-MB-231 breast cancer cell line using 3 tumor cell lines (MDA-MB-231 breast cancer cell line, EO771 mammary tumor cell line, and 4T1.2 mammary tumor cell line), and KTB6 human breast epithelial cells. ( G ) Reduction in PTHrP in BM CM.

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    Techniques: Control, Derivative Assay